Therapy of a number of myeloma cells with VLX1570 induced the accumulation of proteasome-sure higher molecular weight polyubiquitin conjugates and an apoptotic reaction. Sensitivity to VLX1570 was moderately impacted by altered drug uptake, but was unaffected by overexpression of BCL2-loved ones proteins or inhibitors of caspase activity. Finally, treatment with https://mitchg308zeh0.wikiannouncement.com/user