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Detailed Notes on EPZ004777

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TAK-243 preferentially certain to UBA1 over the similar E1 enzymes UBA2, UBA3, and UBA6 in intact AML cells. Inhibition of UBA1 with TAK-243 lessened levels of ubiquitylated proteins, enhanced markers of proteotoxic stress and DNA injury anxiety. In vivo, TAK-243 reduced leukemic load and targeted leukemic stem cells without the https://sethjqvz85285.activoblog.com/29412771/top-sinefungin-secrets

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