Pentobarbital will reduce the level or influence of alfentanil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Not known. pentobarbital will lessen the extent or result of bosentan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. pentobarbital will lower the level or outcome of pazopanib by impacting hepatic/intestinal e... https://sachai899pgu8.wikiusnews.com/user