If a father or mother with the proband is known to possess the pathogenic variant identified in the proband, the chance to your sibs of inheriting the pathogenic variant is 50%. Because of reduced penetrance, sibs who inherit the pathogenic variant may or may not create aHUS (see Penetrance). RTU’s https://ahus42975.blogzet.com/the-5-second-trick-for-ahu-hire-46726101